BMP-2 incorporated into a biomimetic coating on 3D-printed titanium scaffold promotes mandibular bicortical bone formation in a beagle dog model

Biocompatibility and osteoconductivity of porous scaffolds can be improved through coating technique by creating micro- nanostructures on the surfaces. In this study, a biomimetic approach was used to construct bone morphogenetic protein-2 (BMP-2) integrated calcium phosphate (CaP) surface titanium scaffolds. vitro characterizations showed that had mechanical properties comparable those human cortical bone. The has nano-scaled structure, which releases BMP-2 in stable effective manner. Bicortical defects were prepared bilateral mandibles beagle dogs, coated uncoated fixed for 8 weeks. Based micro-CT histological analysis results, significantly promoted formation scaffold. scaffold group higher volume fraction, area bone-to-implant contact results than group. Besides, hematological indexes histopathology visceral organs confirmed coating's biocompatibility. Accordingly, current study demonstrates CaP promote benefit healing process bicortical mandibular defect dogs.